Job Details

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University of California San Francisco
  • Position Number: 1905671
  • Location: San Francisco, CA
  • Position Type: Laboratory and Research
Shoichet lab/ Department of Pharmaceutical Chemistry
University of California, San Francisco

The Specialist will assist in drug discovery projects, formulating novel small molecules for animal studies, analyzing inhibition of enzymes by small molecule libraries, and to test the aggregation of novel small molecule drug hits by light scattering.

The Specialist will be part of a research team that combines computational and experimental approaches for drug discovery in challenging targets. They will collaborate and assist on research projects that will primarily involve bacterial protein expression & purification, enzyme inhibition, formulation and colloidal aggregation of small molecules.
As necessary, the Specialist will also perform further tasks including maintaining the chemicals inventory, ordering supplies, and shipping compounds.
The job duties will include:
Conducting novel small molecule aggregation analysis using dynamic light scattering and enzyme assays in drug discovery.
Studying colloidal formation and its effect in early chemical biology and drug discovery.
Crystallography-quality protein purification & site-directed mutagenesis.
Protein-ligand binding analysis by isothermal titration calorimetry, DSF, etc.
Small molecule drug formulation design and optimization for animal studies.
Training students, maintaining lab equipment, supplies, safety & sustainability.

Required Qualifications:
BSc degree in a related science field with ten or more years of research experience, OR a Ph.D. in a related science field.
Experience with protein biochemistry and biophysical techniques
Experience in bacterial protein expression and purification
Mastery of analytical techniques (UV-Vis Spectroscopy, HPLC, light scattering, etc)
Detail-oriented, organized, and able to work as part of a team in a collaborative environment
Candidate must meet the requirements by the time of appointment. Candidate's CV must list qualifications (or if pending) upon submission

UC San Francisco seeks candidates whose experience, teaching, research, or community service that has prepared them to contribute to our commitment to diversity and excellence. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.

Please apply online at, with a CV and three references (contact information only).

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